Ontology highlight
ABSTRACT:
SUBMITTER: Yokomizo H
PROVIDER: S-EPMC7132633 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Yokomizo Hisashi H Maeda Yasutaka Y Park Kyoungmin K Clermont Allen C AC Hernandez Sonia L SL Fickweiler Ward W Li Qian Q Wang Chih-Hao CH Paniagua Samantha M SM Simao Fabricio F Ishikado Atsushi A Sun Bei B Wu I-Hsien IH Katagiri Sayaka S Pober David M DM Tinsley Liane J LJ Avery Robert L RL Feener Edward P EP Kern Timothy S TS Keenan Hillary A HA Aiello Lloyd Paul LP Sun Jennifer K JK King George L GL
Science translational medicine 20190701 499
The Joslin Medalist Study characterized people affected with type 1 diabetes for 50 years or longer. More than 35% of these individuals exhibit no to mild diabetic retinopathy (DR), independent of glycemic control, suggesting the presence of endogenous protective factors against DR in a subpopulation of patients. Proteomic analysis of retina and vitreous identified retinol binding protein 3 (RBP3), a retinol transport protein secreted mainly by the photoreceptors, as elevated in Medalist patient ...[more]