Ontology highlight
ABSTRACT:
SUBMITTER: Pahle J
PROVIDER: S-EPMC7132935 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Pahle Jasmine J Muhia Mary M Wagener Robin J RJ Tippmann Anja A Bock Hans H HH Graw Janice J Herz Joachim J Staiger Jochen F JF Drakew Alexander A Kneussel Matthias M Rune Gabriele M GM Frotscher Michael M Brunne Bianka B
Cerebral cortex (New York, N.Y. : 1991) 20200301 3
Reelin is an extracellular matrix protein, known for its dual role in neuronal migration during brain development and in synaptic plasticity at adult stages. During the perinatal phase, Reelin expression switches from Cajal-Retzius (CR) cells, its main source before birth, to inhibitory interneurons (IN), the main source of Reelin in the adult forebrain. IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is present ...[more]