Dataset Information

Sex Matters: A Multivariate Pattern Analysis of Sex- and Gender-Related Neuroanatomical Differences in Cis- and Transgender Individuals Using Structural Magnetic Resonance Imaging.

ABSTRACT: Univariate analyses of structural neuroimaging data have produced heterogeneous results regarding anatomical sex- and gender-related differences. The current study aimed at delineating and cross-validating brain volumetric surrogates of sex and gender by comparing the structural magnetic resonance imaging data of cis- and transgender subjects using multivariate pattern analysis. Gray matter (GM) tissue maps of 29 transgender men, 23 transgender women, 35 cisgender women, and 34 cisgender men were created using voxel-based morphometry and analyzed using support vector classification. Generalizability of the models was estimated using repeated nested cross-validation. For external validation, significant models were applied to hormone-treated transgender subjects (n?=?32) and individuals diagnosed with depression (n?=?27). Sex was identified with a balanced accuracy (BAC) of 82.6% (false discovery rate [pFDR] ?0.05). The neuroanatomical signature of sex in cisgender did not interact with depressive features (BAC?=?74.7%) but was affected by hormone therapy when applied in transgender women (P?

SUBMITTER: Baldinger-Melich P

PROVIDER: S-EPMC7132951 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Sex Matters: A Multivariate Pattern Analysis of Sex- and Gender-Related Neuroanatomical Differences in Cis- and Transgender Individuals Using Structural Magnetic Resonance Imaging.

Baldinger-Melich Pia P Urquijo Castro Maria F MF Seiger René R Ruef Anne A Dwyer Dominic B DB Kranz Georg S GS Klöbl Manfred M Kambeitz Joseph J Kaufmann Ulrike U Windischberger Christian C Kasper Siegfried S Falkai Peter P Lanzenberger Rupert R Koutsouleris Nikolaos N

Cerebral cortex (New York, N.Y. : 1991) 20200301 3

Univariate analyses of structural neuroimaging data have produced heterogeneous results regarding anatomical sex- and gender-related differences. The current study aimed at delineating and cross-validating brain volumetric surrogates of sex and gender by comparing the structural magnetic resonance imaging data of cis- and transgender subjects using multivariate pattern analysis. Gray matter (GM) tissue maps of 29 transgender men, 23 transgender women, 35 cisgender women, and 34 cisgender men wer ...[more]

PMID: 31368487

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Dataset Information

Sex Matters: A Multivariate Pattern Analysis of Sex- and Gender-Related Neuroanatomical Differences in Cis- and Transgender Individuals Using Structural Magnetic Resonance Imaging.

Publications

Sex Matters: A Multivariate Pattern Analysis of Sex- and Gender-Related Neuroanatomical Differences in Cis- and Transgender Individuals Using Structural Magnetic Resonance Imaging.

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