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Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms.


ABSTRACT: OBJECTIVE:The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. DESIGN:COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province. RESULTS:Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m6A methylation and changed binding capacity with ACE2. CONCLUSION:We report COVID-19 cases with GI symptoms with novel features outside Wuhan. Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers.

SUBMITTER: Jin X 

PROVIDER: S-EPMC7133387 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms.

Jin Xi X   Lian Jiang-Shan JS   Hu Jian-Hua JH   Gao Jianguo J   Zheng Lin L   Zhang Yi-Min YM   Hao Shao-Rui SR   Jia Hong-Yu HY   Cai Huan H   Zhang Xiao-Li XL   Yu Guo-Dong GD   Xu Kai-Jin KJ   Wang Xiao-Yan XY   Gu Jue-Qing JQ   Zhang Shan-Yan SY   Ye Chan-Yuan CY   Jin Ci-Liang CL   Lu Ying-Feng YF   Yu Xia X   Yu Xiao-Peng XP   Huang Jian-Rong JR   Xu Kang-Li KL   Ni Qin Q   Yu Cheng-Bo CB   Zhu Biao B   Li Yong-Tao YT   Liu Jun J   Zhao Hong H   Zhang Xuan X   Yu Liang L   Guo Yong-Zheng YZ   Su Jun-Wei JW   Tao Jing-Jing JJ   Lang Guan-Jing GJ   Wu Xiao-Xin XX   Wu Wen-Rui WR   Qv Ting-Ting TT   Xiang Dai-Rong DR   Yi Ping P   Shi Ding D   Chen Yanfei Y   Ren Yue Y   Qiu Yun-Qing YQ   Li Lan-Juan LJ   Sheng Jifang J   Yang Yida Y  

Gut 20200324 6


<h4>Objective</h4>The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics.<h4>Design</h4>COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, manag  ...[more]

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