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Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.


ABSTRACT: OBJECTIVE:To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. METHODS:Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). RESULTS:A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p?

SUBMITTER: Lechien JR 

PROVIDER: S-EPMC7134551 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.

Lechien Jerome R JR   Chiesa-Estomba Carlos M CM   De Siati Daniele R DR   Horoi Mihaela M   Le Bon Serge D SD   Rodriguez Alexandra A   Dequanter Didier D   Blecic Serge S   El Afia Fahd F   Distinguin Lea L   Chekkoury-Idrissi Younes Y   Hans Stéphane S   Delgado Irene Lopez IL   Calvo-Henriquez Christian C   Lavigne Philippe P   Falanga Chiara C   Barillari Maria Rosaria MR   Cammaroto Giovanni G   Khalife Mohamad M   Leich Pierre P   Souchay Christel C   Rossi Camelia C   Journe Fabrice F   Hsieh Julien J   Edjlali Myriam M   Carlier Robert R   Ris Laurence L   Lovato Andrea A   De Filippis Cosimo C   Coppee Frederique F   Fakhry Nicolas N   Ayad Tareck T   Saussez Sven S  

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20200406 8


<h4>Objective</h4>To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection.<h4>Methods</h4>Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste comp  ...[more]

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