Omega-3 and hemocompatibility-related adverse events.

ABSTRACT: BACKGROUND:Hemocompatibility-related clinical adverse events (HRAEs) are major causes of readmission in patients with left ventricular assist devices (LVADs). Omega-3 is an unsaturated fatty acid that possesses anti-inflammatory and antiangiogenic properties. We aimed to investigate the impact of omega-3 therapy on HRAEs during LVAD support. METHODS:Consecutive LVAD patients who were followed for 6 months were enrolled, and stratified by the use of omega-3. Freedom from any HRAEs and net burden of HRAEs, which was calculated by using a hemocompatibility score (using 4 escalating tiers of hierarchal severity to derive a total score for events), were compared between those with and without omega-3 therapy. RESULTS:Among 169 LVAD patients (57 years old and 124 males), 31 patients received 4?g/d of omega-3 therapy and 138 patients were in the control group. During the 6-month observational period, freedom from any HRAEs was 90% in the omega-3 group compared with 70% in the control group with a hazard ratio of 0.35 (95% confidence interval 0.11-0.87 and P?=?.042). The average hemocompatibility score in the omega-3 group was significantly lower compared with the control group (0.23 vs 0.91; P?=?.042), due to reduced Tier I scores (mild HRAE; P?=?.003) and Tier IIIB scores (severe HRAE; P?

SUBMITTER: Imamura T 

PROVIDER: S-EPMC7135915 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature