A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Elsayed AH
PROVIDER: S-EPMC7135934 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.
Elsayed Abdelrahman H AH Rafiee Roya R Cao Xueyuan X Raimondi Susana S Downing James R JR Ribeiro Raul R Fan Yiping Y Gruber Tanja A TA Baker Sharyn S Klco Jeffery J Rubnitz Jeffrey E JE Pounds Stanley S Lamba Jatinder K JK
Leukemia 20191023 3
Recently, mRNA-expression signature enriched in LSCs was used to create a 17-gene leukemic stem cell (LSC17) score predictive of prognosis in adult AML. By fitting a Cox-LASSO regression model to the clinical outcome and gene-expression levels of LSC enriched genes in 163 pediatric participants of the AML02 multi-center clinical trial (NCT00136084), we developed a six-gene LSC score of prognostic value in pediatric AML (pLSC6). In the AML02 cohort, the 5-year event-free survival (EFS) of patient ...[more]
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