Ontology highlight
ABSTRACT:
SUBMITTER: Malagon G
PROVIDER: S-EPMC7136020 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Malagon Gerardo G Miki Takafumi T Tran Van V Gomez Laura C LC Marty Alain A
eLife 20200331
Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic vesicle per action potential and per site. Here we use deconvolution to count synaptic vesicle output at single sites (mean site number per synapse: 3.6). When increasing calcium entry with tetraethylammonium in 1.5 mM external calcium concentration, w ...[more]