Dataset Information

Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study.

ABSTRACT:

Introduction

We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24).

Methods

Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location.

Results

Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR?0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays.

Conclusions

This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.

SUBMITTER: Zumel-Marne A

PROVIDER: S-EPMC7136306 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Publications

Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study.

Zumel-Marne Angela A Kundi Michael M Castaño-Vinyals Gemma G Alguacil Juan J Petridou Eleni Th ET Georgakis Marios K MK Morales-Suárez-Varela Maria M Sadetzki Siegal S Piro Sara S Nagrani Rajini R Filippini Graziella G Hutter Hans-Peter HP Dikshit Rajesh R Woehrer Adelheid A Maule Milena M Weinmann Tobias T Krewski Daniel D T Mannetje Andrea A Momoli Franco F Lacour Brigitte B Mattioli Stefano S Spinelli John J JJ Ritvo Paul P Remen Thomas T Kojimahara Noriko N Eng Amanda A Thurston Angela A Lim Hyungryul H Ha Mina M Yamaguchi Naohito N Mohipp Charmaine C Bouka Evdoxia E Eastman Chelsea C Vermeulen Roel R Kromhout Hans H Cardis Elisabeth E

Journal of neuro-oncology 20200303 2

<h4>Introduction</h4>We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24).<h4>Methods</h4>Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location.<h4>Results</h4>Overall, 64% of all tumors were low-grade, 76% ...[more]

PMID: 32124185

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Dataset Information

Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study.

Introduction

Methods

Results

Conclusions

Publications

Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study.

Similar Datasets

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