Let's conquer COVID-19 and sustain our abilities.
Ontology highlight
ABSTRACT:
SUBMITTER: Alexander M
PROVIDER: S-EPMC7136544 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Let's conquer COVID-19 and sustain our abilities.
Spinal cord series and cases 20200407 1
Similar Datasets
Project description: Not available
| S-EPMC7238988 | biostudies-literature
Project description:In recent months, the coronavirus disease 2019 (COVID-19) pandemic has sent many countries into crisis. Studies have shown that this virus causes worse outcomes and a higher mortality in men than in women. It has been recognized that sex can affect the immune response to a pathogenic agent, as well as the susceptibility for some respiratory diseases. These different responses in males and females may be related to the actions of sex hormones. Angiotensin-converting enzyme 2 (ACE2) acts as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. The expression of ACE2 is influenced by sex hormones; therefore, we discuss in this article that this could be one of the reasons why COVID-19 is more prevalent in men than in women.
| S-EPMC7303729 | biostudies-literature
Project description:ObjectiveTo assess the impact of the COVID-19 pandemic on the activity of a tertiary fertility service and compare telemedicine and face-to-face meetings during this time.MethodsThis was a retrospective cohort study conducted in a university affiliated tertiary medical center. Included were patients scheduled for an appointment in the in-vitro fertilization (IVF) unit between March 18th and April 15th. A comparison was made between patients who chose telemedicine as opposed to face-to-face meetings. Additionally, the population of patients who chose to cancel their appointment was characterized. IVF cycle outcomes were additionally compared between the groups.ResultsOverall, 90 IVF clinic appointments were scheduled during the study period. Thirty-four (37.8 %) patients chose to arrive to the clinic in spite of the COVID 19 pandemic and partial quarantine, 27 (30.0 %) patients chose to avoid in person meeting and scheduled a telemedicine appointment and 29 (32.2 %) patients cancelled their appointment. On comparison between patients who chose telemedicine vs. face-to-face meeting, the telemedicine group had lower prevalence of primary infertility (20.0 % vs. 47.1 %, p = 0.037) and higher rates of preimplantation genetic testing indication for in-vitro fertilization (48.2 % vs. 20.6 %, p = 0.026). Rate of a first-ever clinic visit was higher in patients that arrived for a face-to-face meeting, as compared to telemedicine encounter (55.9 % vs. 28.0 %, respectively; p = 0.036). Patients that opted to avoid attending the clinic or meeting via telemedicine had higher rates of medical comorbidities compared to patients who chose to attend their appointment (51.7 % vs. 29.5 %, p = 0.016). Rate of appointments that led to fresh or frozen-thawed embryo transfer and these transfers' outcomes (clinical pregnancy rate) were similar in the telemedicine and face-to-face meeting groups (72.2 % vs. 88.0 % and 30.8 % vs. 31.8 %, p = 0.73 and p = 1.00; respectively).ConclusionTelemedicine is a valuable tool for delivering fertility care during the COVID-19 pandemic. There is need to determine which patients will benefit most from this modality.
| S-EPMC7968226 | biostudies-literature
Project description: Not available
| S-BSST563 | biostudies-other
Project description:Antibodies are key immune effectors that confer protection against pathogenic threats. The nature and longevity of the antibody response to SARS-CoV-2 infection are not well defined. We charted longitudinal antibody responses to SARS-CoV-2 in 92 subjects after symptomatic COVID-19. Antibody responses to SARS-CoV-2 are unimodally distributed over a broad range, with symptom severity correlating directly with virus-specific antibody magnitude. Seventy-six subjects followed longitudinally to ∼100 days demonstrated marked heterogeneity in antibody duration dynamics. Virus-specific IgG decayed substantially in most individuals, whereas a distinct subset had stable or increasing antibody levels in the same time frame despite similar initial antibody magnitudes. These individuals with increasing responses recovered rapidly from symptomatic COVID-19 disease, harbored increased somatic mutations in virus-specific memory B cell antibody genes, and had persistent higher frequencies of previously activated CD4+ T cells. These findings illuminate an efficient immune phenotype that connects symptom clearance speed to differential antibody durability dynamics.
| S-EPMC7608032 | biostudies-literature
Project description:While effective preventive measures against COVID-19 are now widely known, many individuals fail to adopt them. This article provides experimental evidence about one potentially important driver of compliance with social distancing: social norms. We asked each of 23,000 survey respondents in Mexico to predict how a fictional person would behave when faced with the choice about whether or not to attend a friend's birthday gathering. Every respondent was randomly assigned to one of four social norms conditions. Expecting that other people would attend the gathering and/or believing that other people approved of attending the gathering both increased the predicted probability that the fictional character would attend the gathering by 25%, in comparison with a scenario where other people were not expected to attend nor to approve of attending. Our results speak to the potential effects of communication campaigns and media coverage of compliance with, and normative views about, COVID-19 preventive measures. They also suggest that policies aimed at modifying social norms or making existing ones salient could impact compliance.
| S-EPMC7924783 | biostudies-literature
Project description: Not available
| S-BSST416 | biostudies-other
Project description:5'RACE-based TCR repertoire sequencing from peripheral blood
2024-09-26 | E-MTAB-13593 | biostudies-arrayexpress