Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC7136961 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Li Qian Q Cao Yuze Y Dang Chun C Han Bin B Han Ranran R Ma Heping H Hao Junwei J Wang Lihua L
EMBO molecular medicine 20200401 4
Cytosolic double-stranded DNA (dsDNA) is a danger signal that is tightly monitored and sensed by nucleic acid-sensing pattern recognition receptors. We study the inflammatory cascade on dsDNA recognition and investigate the neuroprotective effect of cyclic GMP-AMP (cGAMP) synthase (cGAS) antagonist A151 and its mechanisms of neuroprotection in a mouse model of experimental stroke. Here, we found that cerebral ischemia promoted the release of dsDNA into the cytosol, where it initiated inflammator ...[more]