Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC7137051 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yang Jia J Hu Su S Shangguan Junjie J Eresen Aydin A Li Yu Y Ma Quanhong Q Yaghmai Vahid V Benson Iii Al B AB Zhang Zhuoli Z
American journal of translational research 20200315 3
Dinaciclib is a small molecule cyclin-dependent kinase inhibitor with the potential to treat multiple cancers. To better understand its cytotoxic action in pancreatic ductal adenocarcinoma (PDAC), we evaluated dinaciclib therapeutic effects in the transgenic mouse model (<i>LSL-Kras<sup>G12D/+</sup></i> ; <i>LSL-Trp53<sup>R172H/+</sup></i> ; <i>Pdx-1-Cre</i> mice; KPC mice). Tumor growth and microenvironment were dynamically monitored by magnetic resonance imaging (MRI). Dinaciclib therapy signi ...[more]