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ABSTRACT: Objective
Cd exposure is a non-traditional risk factor of cardiovascular disease and mortality by promoting the development of atherosclerosis. The development of atherosclerosis can be monitored non-invasively by measuring carotid intima-media thickness (CIMT). This study aimed to measure the level of blood Cd and other factors known to be associated with CIMT, measured at the segment of common carotid artery (CCA) and of internal carotid artery (ICA), in young adults from Padang, West Sumatera, Indonesia, and we analyzed whether blood Cd is a predictor of CIMT.Results
We recruited 156 subjects. Median blood Cd level was 0.61 ?g/L (range 0.01-5.96 ?g/L), with no difference in male compared to female subjects (Mann-Whitney U test, p?=?0.60). Multiple regression analysis showed that sex is the predictor of CCA IMT (adjusted R2?=?0.219; ??=?-0.438 [95% CI - 0.662, - 0.214]; p?2?=?0.165; ??=?- 0.529 [95% CI - 0.761, - 0.297]; p?2?=?0.219; ??=?- 0.101 [95% CI - 0.257, 0.055]; p?=?0.203) and ICA IMT (adjusted R2?=?0.165; ??=?- 0.055 [95% CI - 0.217, 0.107]; p?=?0.503) in young adults from Padang, Indonesia.
SUBMITTER: Ilmiawati C
PROVIDER: S-EPMC7137246 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Ilmiawati Cimi C Reza Mohamad M Yanni Mefri M Rusjdi Dina Arfiani DA
BMC research notes 20200406 1
<h4>Objective</h4>Cd exposure is a non-traditional risk factor of cardiovascular disease and mortality by promoting the development of atherosclerosis. The development of atherosclerosis can be monitored non-invasively by measuring carotid intima-media thickness (CIMT). This study aimed to measure the level of blood Cd and other factors known to be associated with CIMT, measured at the segment of common carotid artery (CCA) and of internal carotid artery (ICA), in young adults from Padang, West ...[more]