Dataset Information

Blood Cd levels and carotid intima-media thickness in young adults living in Padang, Indonesia.

ABSTRACT:

Objective

Cd exposure is a non-traditional risk factor of cardiovascular disease and mortality by promoting the development of atherosclerosis. The development of atherosclerosis can be monitored non-invasively by measuring carotid intima-media thickness (CIMT). This study aimed to measure the level of blood Cd and other factors known to be associated with CIMT, measured at the segment of common carotid artery (CCA) and of internal carotid artery (ICA), in young adults from Padang, West Sumatera, Indonesia, and we analyzed whether blood Cd is a predictor of CIMT.

Results

We recruited 156 subjects. Median blood Cd level was 0.61 ?g/L (range 0.01-5.96 ?g/L), with no difference in male compared to female subjects (Mann-Whitney U test, p?=?0.60). Multiple regression analysis showed that sex is the predictor of CCA IMT (adjusted R²?=?0.219; ??=?-0.438 [95% CI - 0.662, - 0.214]; p?2?=?0.165; ??=?- 0.529 [95% CI - 0.761, - 0.297]; p?2?=?0.219; ??=?- 0.101 [95% CI - 0.257, 0.055]; p?=?0.203) and ICA IMT (adjusted R²?=?0.165; ??=?- 0.055 [95% CI - 0.217, 0.107]; p?=?0.503) in young adults from Padang, Indonesia.

SUBMITTER: Ilmiawati C

PROVIDER: S-EPMC7137246 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Publications

Blood Cd levels and carotid intima-media thickness in young adults living in Padang, Indonesia.

Ilmiawati Cimi C Reza Mohamad M Yanni Mefri M Rusjdi Dina Arfiani DA

BMC research notes 20200406 1

<h4>Objective</h4>Cd exposure is a non-traditional risk factor of cardiovascular disease and mortality by promoting the development of atherosclerosis. The development of atherosclerosis can be monitored non-invasively by measuring carotid intima-media thickness (CIMT). This study aimed to measure the level of blood Cd and other factors known to be associated with CIMT, measured at the segment of common carotid artery (CCA) and of internal carotid artery (ICA), in young adults from Padang, West ...[more]

PMID: 32252819

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Project description:BackgroundIntima-media thickness of the walls of the common carotid artery and internal carotid artery may add to the Framingham risk score for predicting cardiovascular events.MethodsWe measured the mean intima-media thickness of the common carotid artery and the maximum intima-media thickness of the internal carotid artery in 2965 members of the Framingham Offspring Study cohort. Cardiovascular-disease outcomes were evaluated for an average follow-up of 7.2 years. Multivariable Cox proportional-hazards models were generated for intima-media thickness and risk factors. We evaluated the reclassification of cardiovascular disease on the basis of the 8-year Framingham risk score category (low, intermediate, or high) after adding intima-media thickness values.ResultsA total of 296 participants had a cardiovascular event. The risk factors of the Framingham risk score predicted these events, with a C statistic of 0.748 (95% confidence interval [CI], 0.719 to 0.776). The adjusted hazard ratio for cardiovascular disease with a 1-SD increase in the mean intima-media thickness of the common carotid artery was 1.13 (95% CI, 1.02 to 1.24), with a nonsignificant change in the C statistic of 0.003 (95% CI, 0.000 to 0.007); the corresponding hazard ratio for the maximum intima-media thickness of the internal carotid artery was 1.21 (95% CI, 1.13 to 1.29), with a modest increase in the C statistic of 0.009 (95% CI, 0.003 to 0.016). The net reclassification index increased significantly after addition of intima-media thickness of the internal carotid artery (7.6%, P<0.001) but not intima-media thickness of the common carotid artery (0.0%, P=0.99). With the presence of plaque, defined as intima-media thickness of the internal carotid artery of more than 1.5 mm, the net reclassification index was 7.3% (P=0.01), with an increase in the C statistic of 0.014 (95% CI, 0.003 to 0.025).ConclusionsThe maximum internal and mean common carotid-artery intima-media thicknesses both predict cardiovascular outcomes, but only the maximum intima-media thickness of (and presence of plaque in) the internal carotid artery significantly (albeit modestly) improves the classification of risk of cardiovascular disease in the Framingham Offspring Study cohort. (Funded by the National Heart, Lung, and Blood Institute.).

Dataset Information

Blood Cd levels and carotid intima-media thickness in young adults living in Padang, Indonesia.

Objective

Results

Publications

Blood Cd levels and carotid intima-media thickness in young adults living in Padang, Indonesia.

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