Dataset Information

Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review.

ABSTRACT:

Background

Recent data suggest that the risk of young-onset colorectal cancer (yCRC), in adults less than 50?years of age, is increasing. To confirm findings and identify contemporary trends worldwide, we conducted a systematic review of studies examining population-level trends in yCRC epidemiology.

Methods

We searched MEDLINE (1946-2018), EMBASE (1974-2018), CINAHL (1982-2018), and Cochrane Database of Systematic Reviews (2005-2018) for studies that used an epidemiologic design, assessed trends in yCRC incidence or prevalence, and published in English. Extracted information included country, age cut-off for yCRC, and reported trends in incidence or prevalence (e.g. annual percent change [APC]). We pooled similarly reported trend estimates using random effects models.

Results

Our search yielded 8695 articles and after applying our inclusion criteria, we identified 40 studies from 12 countries across five continents. One study assessed yCRC prevalence trends reporting an APCp of +?2.6 and?+?1.8 among 20-39 and 40-49?year olds, respectively. 39 studies assessed trends in yCRC incidence but with substantial variability in reporting. Meta-analysis of the most commonly reported trend estimate yielded a pooled overall APCi of +?1.33 (95% CI, 0.97 to 1.68; p ConclusionsOur systematic review highlights increasing yCRC risk in North America and Australia driven by rising rectal cancers in younger adults over the past two decades.

SUBMITTER: Saad El Din K

PROVIDER: S-EPMC7137305 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Publications

Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review.

Saad El Din Khalid K Loree Jonathan M JM Sayre Eric C EC Gill Sharlene S Brown Carl J CJ Dau Hallie H De Vera Mary A MA

BMC cancer 20200406 1

<h4>Background</h4>Recent data suggest that the risk of young-onset colorectal cancer (yCRC), in adults less than 50 years of age, is increasing. To confirm findings and identify contemporary trends worldwide, we conducted a systematic review of studies examining population-level trends in yCRC epidemiology.<h4>Methods</h4>We searched MEDLINE (1946-2018), EMBASE (1974-2018), CINAHL (1982-2018), and Cochrane Database of Systematic Reviews (2005-2018) for studies that used an epidemiologic design, ...[more]

PMID: 32252672

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Dataset Information

Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review.

Background

Methods

Results

Publications

Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review.

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