Ontology highlight
ABSTRACT:
SUBMITTER: Chowdhry S
PROVIDER: S-EPMC7138021 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Chowdhry Sudhir S Zanca Ciro C Rajkumar Utkrisht U Koga Tomoyuki T Diao Yarui Y Raviram Ramya R Liu Feng F Turner Kristen K Yang Huijun H Brunk Elizabeth E Bi Junfeng J Furnari Frank F Bafna Vineet V Ren Bing B Mischel Paul S PS
Nature 20190424 7757
Precision oncology hinges on linking tumour genotype with molecularly targeted drugs<sup>1</sup>; however, targeting the frequently dysregulated metabolic landscape of cancer has proven to be a major challenge<sup>2</sup>. Here we show that tissue context is the major determinant of dependence on the nicotinamide adenine dinucleotide (NAD) metabolic pathway in cancer. By analysing more than 7,000 tumours and 2,600 matched normal samples of 19 tissue types, coupled with mathematical modelling and ...[more]