Ontology highlight
ABSTRACT:
SUBMITTER: Hamada N
PROVIDER: S-EPMC7138321 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hamada Norio N Hamazaki Nobuhiko N Shimamoto So S Hikabe Orie O Nagamatsu Go G Takada Yuki Y Kato Kiyoko K Hayashi Katsuhiko K
PLoS genetics 20200326 3
A set of sex chromosomes is required for gametogenesis in both males and females, as represented by sex chromosome disorders causing agametic phenotypes. Although studies using model animals have investigated the functional requirement of sex chromosomes, involvement of these chromosomes in gametogenesis remains elusive. Here, we elicit a germ cell-intrinsic effect of sex chromosomes on oogenesis, using a novel culture system in which oocytes were induced from embryonic stem cells (ESCs) harbori ...[more]