Dataset Information

Little Change in Functional Brain Networks Following Acute Levodopa in Drug-Naive Parkinson's Disease.

ABSTRACT:

Objective

The objective of this study was to investigate the effects of levodopa on functional brain networks in Parkinson's disease.

Methods

We acquired resting state functional magnetic resonance imaging in 30 drug-naïve participants with Parkinson's disease and 20 age-matched healthy controls. Each participant was studied following administration of a single oral dose of either levodopa or placebo in a randomized, double-blind, crossover design.

Results

The greatest observed differences in functional connectivity were between Parkinson's disease versus control participants, independent of pharmacologic intervention. By contrast, the effects of levodopa were much smaller and detectable only in the Parkinson's disease group. Moreover, although levodopa administration in the Parkinson's disease group measurably improved motor performance, it did not increase the similarity of functional connectivity in Parkinson's disease to the control group.

Conclusions

SUBMITTER: White RL

PROVIDER: S-EPMC7138409 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Little Change in Functional Brain Networks Following Acute Levodopa in Drug-Naïve Parkinson's Disease.

White Robert L RL Campbell Meghan C MC Yang Dake D Shannon William W Snyder Abraham Z AZ Perlmutter Joel S JS

Movement disorders : official journal of the Movement Disorder Society 20191219 3

<h4>Objective</h4>The objective of this study was to investigate the effects of levodopa on functional brain networks in Parkinson's disease.<h4>Methods</h4>We acquired resting state functional magnetic resonance imaging in 30 drug-naïve participants with Parkinson's disease and 20 age-matched healthy controls. Each participant was studied following administration of a single oral dose of either levodopa or placebo in a randomized, double-blind, crossover design.<h4>Results</h4>The greatest obse ...[more]

PMID: 31854465

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