Ontology highlight
ABSTRACT:
SUBMITTER: Guo SD
PROVIDER: S-EPMC7138540 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Guo Shi-Dong SD Yan Sheng-Tao ST Li Wen W Zhou Hong H Yang Jian-Ping JP Yao Yao Y Shen Mei-Jia MJ Zhang Liu-Wei LW Zhang Hong-Bo HB Sun Li-Chao LC
Aging 20200328 6
<h4>Objective</h4>This study was aimed at investigating the regulation of mitochondrial function by histone deacetylase 6 (HDAC6) and the role of HDAC6 in the development and progression of sepsis.<h4>Results</h4>HDAC6 downregulated PHB1 and subsequently promoted the development of CLP-induced sepsis. Inhibition of HDAC6 significantly attenuated CLP-induced sepsis through inhibition of mitochondrial dysfunction and reduced oxidant production, thus protecting the rats from oxidative injury.<h4>Co ...[more]