Ontology highlight
ABSTRACT:
SUBMITTER: Azimi Z
PROVIDER: S-EPMC7138610 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Azimi Zohre Z Barzan Ruxandra R Spoida Katharina K Surdin Tatjana T Wollenweber Patric P Mark Melanie D MD Herlitze Stefan S Jancke Dirk D
eLife 20200407
Controlling gain of cortical activity is essential to modulate weights between internal ongoing communication and external sensory drive. Here, we show that serotonergic input has separable suppressive effects on the gain of ongoing and evoked visual activity. We combined optogenetic stimulation of the dorsal raphe nucleus (DRN) with wide-field calcium imaging, extracellular recordings, and iontophoresis of serotonin (5-HT) receptor antagonists in the mouse visual cortex. 5-HT1A receptors promot ...[more]