Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC7138820 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Gao Yujing Y Chen Lijia L Han Yali Y Wu Fangrui F Yang Wen-Si WS Zhang Zheng Z Huo Tong T Zhu Yingmin Y Yu Chengtai C Kim Hong H Lee Mark M Tang Zhen Z Phillips Kevin K He Bin B Jung Sung Yun SY Song Yongcheng Y Zhu Bokai B Xu Rui-Ming RM Feng Qin Q
Communications biology 20200407 1
As approximately 70% of human breast tumors are estrogen receptor α (ERα)-positive, estrogen and ERα play essential roles in breast cancer development. By interrupting the ERα signaling pathway, endocrine therapy has been proven to be an effective therapeutic strategy. In this study, we identified a mechanism by which Transcription Start Site (TSS)-associated histone H3K27 acetylation signals the Super Elongation Complex (SEC) to regulate transcriptional elongation of the ESR1 (ERα) gene. SEC in ...[more]