Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Limon A
PROVIDER: S-EPMC7139330 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Martínez-Limón Adrián A Joaquin Manel M Caballero María M Posas Francesc F de Nadal Eulàlia E
International journal of molecular sciences 20200311 6
The p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent. Nevertheless, p38 participates in a broad range of cellular activities, for many of which detailed molecular pictures are still lacking. Originally described as a tumor-suppressor kinase for its inhibitory role in RAS-dependent transformation, p38 can also function as a tumor promoter, as demon ...[more]