Ontology highlight
ABSTRACT:
SUBMITTER: Pascoal S
PROVIDER: S-EPMC7139560 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Pascoal Susana S Salzer Benjamin B Scheuringer Eva E Wenninger-Weinzierl Andrea A Sturtzel Caterina C Holter Wolfgang W Taschner-Mandl Sabine S Lehner Manfred M Distel Martin M
Cancers 20200229 3
Chimeric antigen receptor (CAR) T cells have proven to be a powerful cellular therapy for B cell malignancies. Massive efforts are now being undertaken to reproduce the high efficacy of CAR T cells in the treatment of other malignancies. Here, predictive preclinical model systems are important, and the current gold standard for preclinical evaluation of CAR T cells are mouse xenografts. However, mouse xenograft assays are expensive and slow. Therefore, an additional vertebrate in vivo assay woul ...[more]