Ontology highlight
ABSTRACT:
SUBMITTER: Lamboy-Caraballo R
PROVIDER: S-EPMC7139728 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lamboy-Caraballo Rocio R Ortiz-Sanchez Carmen C Acevedo-Santiago Arelis A Matta Jaime J N A Monteiro Alvaro A N Armaiz-Pena Guillermo G
International journal of molecular sciences 20200324 6
Multiple studies have shown that psychological distress in epithelial ovarian cancer (EOC) patients is associated with worse quality of life and poor treatment adherence. This may influence chemotherapy response and prognosis. Moreover, although stress hormones can reduce cisplatin efficacy in EOC treatment, their effect on the integrity of DNA remains poorly understood. In this study, we investigated whether norepinephrine and epinephrine can induce DNA damage and modulate cisplatin-induced DNA ...[more]