Ontology highlight
ABSTRACT:
SUBMITTER: Ancuceanu R
PROVIDER: S-EPMC7139829 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ancuceanu Robert R Hovanet Marilena Viorica MV Anghel Adriana Iuliana AI Furtunescu Florentina F Neagu Monica M Constantin Carolina C Dinu Mihaela M
International journal of molecular sciences 20200319 6
Drug-induced liver injury (DILI) remains one of the challenges in the safety profile of both authorized and candidate drugs, and predicting hepatotoxicity from the chemical structure of a substance remains a task worth pursuing. Such an approach is coherent with the current tendency for replacing non-clinical tests with in vitro or in silico alternatives. In 2016, a group of researchers from the FDA published an improved annotated list of drugs with respect to their DILI risk, constituting "the ...[more]