Ontology highlight
ABSTRACT:
SUBMITTER: Gerstner ER
PROVIDER: S-EPMC7139851 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Gerstner Elizabeth R ER Emblem Kyrre E KE Chang Ken K Vakulenko-Lagun Bella B Yen Yi-Fen YF Beers Andrew L AL Dietrich Jorg J Plotkin Scott R SR Catana Ciprian C Hooker Jacob M JM Duda Dan G DG Rosen Bruce B Kalpathy-Cramer Jayashree J Jain Rakesh K RK Batchelor Tracy T
Clinical cancer research : an official journal of the American Association for Cancer Research 20190926 1
<h4>Purpose</h4>Targeting tumor blood vessels is an attractive therapy in glioblastoma (GBM), but the mechanism of action of these agents and how they modulate delivery of concomitant chemotherapy are not clear in humans. We sought to elucidate how bevacizumab modulates tumor vasculature and the impact those vascular changes have on drug delivery in patients with recurrent GBM.<h4>Experimental design</h4>Temozolomide was labeled with [11C], and serial PET-MRI scans were performed in patients wit ...[more]