Ontology highlight
ABSTRACT:
SUBMITTER: Phoa AF
PROVIDER: S-EPMC7139970 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Phoa Athena F AF Recasens Ariadna A Gurgis Fadi M S FMS Betts Tara A TA Menezes Sharleen V SV Chau Diep D Nordfors Kristiina K Haapasalo Joonas J Haapasalo Hannu H Johns Terrance G TG Stringer Brett W BW Day Bryan W BW Buckland Michael E ME Lalaoui Najoua N Munoz Lenka L
Cancers 20200311 3
MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While <i>TP53</i> deletion is rare in glioblastomas, these tumors often carry <i>TP53</i> mutations. Here, we show that MK2 inhibition strongly attenuated glioblastoma cell proliferation through p53<sup>wt</sup> stabilization and senescence. The senescence-inducing efficacy of MK2 inhibition was particularly strong when cells were co-treated wi ...[more]