Ontology highlight
ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC7140007 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Kim Yonghyo Y Gil Jeovanis J Pla Indira I Sanchez Aniel A Betancourt Lazaro Hiram LH Lee Boram B Appelqvist Roger R Ingvar Christian C Lundgren Lotta L Olsson Håkan H Baldetorp Bo B Kwon Ho Jeong HJ Oskolás Henriett H Rezeli Melinda M Doma Viktoria V Kárpáti Sarolta S Szasz A Marcell AM Németh István Balázs IB Malm Johan J Marko-Varga György G
Cancers 20200324 3
Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to the lymph nodes and distal organs, i.e., metastatic melanoma (MM), the usual outcome is decreased survival. To improve survival rates and life span, advanced treatments have focused on the success of targeted therapies in the MAPK pathway that are based on BRAF (BR ...[more]