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Current Understanding of RAD52 Functions: Fundamental and Therapeutic Insights.

ABSTRACT: In this Special Issue, we would like to focus on the various functions of the RAD52 helicase-like protein and the current implications of such findings for cancer treatment. Over the last few years, various laboratories have discovered particular activities of mammalian RAD52-both in S and M phase-that are distinct from the auxiliary role of yeast RAD52 in homologous recombination. At DNA double-strand breaks, RAD52 was demonstrated to spur alternative pathways to compensate for the loss of homologous recombination functions. At collapsed replication forks, RAD52 activates break-induced replication. In the M phase, RAD52 promotes the finalization of DNA replication. Its compensatory role in the resolution of DNA double-strand breaks has put RAD52 in the focus of synthetic lethal strategies, which is particularly relevant for cancer treatment.

SUBMITTER: Gottifredi V

PROVIDER: S-EPMC7140074 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Current Understanding of RAD52 Functions: Fundamental and Therapeutic Insights.

Gottifredi Vanesa V Wiesmüller Lisa L

Cancers 20200317 3

In this Special Issue, we would like to focus on the various functions of the RAD52 helicase-like protein and the current implications of such findings for cancer treatment. Over the last few years, various laboratories have discovered particular activities of mammalian RAD52-both in S and M phase-that are distinct from the auxiliary role of yeast RAD52 in homologous recombination. At DNA double-strand breaks, RAD52 was demonstrated to spur alternative pathways to compensate for the loss of homo ...[more]

PMID: 32192055

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