Ontology highlight
ABSTRACT:
SUBMITTER: Seminary ER
PROVIDER: S-EPMC7140469 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Seminary Emily R ER Santarriaga Stephanie S Wheeler Lynn L Mejaki Marie M Abrudan Jenica J Demos Wendy W Zimmermann Michael T MT Urrutia Raul A RA Fee Dominic D Barkhaus Paul E PE Ebert Allison D AD
Cells 20200228 3
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by the loss of the upper and lower motor neurons. Approximately 10% of cases are caused by specific mutations in known genes, with the remaining cases having no known genetic link. As such, sporadic cases have been more difficult to model experimentally. Here, we describe the generation and differentiation of ALS induced pluripotent stem cells reprogrammed from discordant identical twins. Whole genome seque ...[more]