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Improving the usability and comprehensiveness of microbial databases.


ABSTRACT: Metagenomics studies leverage genomic reference databases to generate discoveries in basic science and translational research. However, current microbial studies use disparate reference databases that lack consistent standards of specimen inclusion, data preparation, taxon labelling and accessibility, hindering their quality and comprehensiveness, and calling for the establishment of recommendations for reference genome database assembly. Here, we analyze existing fungal and bacterial databases and discuss guidelines for the development of a master reference database that promises to improve the quality and quantity of omics research.

SUBMITTER: Loeffler C 

PROVIDER: S-EPMC7140547 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Improving the usability and comprehensiveness of microbial databases.

Loeffler Caitlin C   Karlsberg Aaron A   Martin Lana S LS   Eskin Eleazar E   Koslicki David D   Mangul Serghei S  

BMC biology 20200407 1


Metagenomics studies leverage genomic reference databases to generate discoveries in basic science and translational research. However, current microbial studies use disparate reference databases that lack consistent standards of specimen inclusion, data preparation, taxon labelling and accessibility, hindering their quality and comprehensiveness, and calling for the establishment of recommendations for reference genome database assembly. Here, we analyze existing fungal and bacterial databases  ...[more]

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