Ontology highlight
ABSTRACT:
SUBMITTER: Ho J
PROVIDER: S-EPMC7140650 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ho Jemima J Wickramasinghe Don N DN Nikou Spyridoula-Angeliki SA Hube Bernhard B Richardson Jonathan P JP Naglik Julian R JR
Cells 20200312 3
Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to pathogens. In the context of <i>Candida albicans</i>, the fungal factors inducing the release of these innate immune molecules are poorly defined. Herein, we identify candidalysin as a potent trigger of several key alarmins and AMPs known to possess pote ...[more]