New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study.

ABSTRACT: INTRODUCTION:To evaluate the effects of a new lubricating, antioxidant solution (VisuEvo®) on dry eye disease (DED) in patients undergoing cataract surgery. METHODS:Patients requiring cataract surgery with either healthy ocular surface or mild DED (tear break-up time, TBUT >?7, Schirmer I test >?15 mm/5 min) were enrolled in this multicenter, open-label, randomized, prospective study. Scheduled visits were 2 weeks before surgery (screening), day of surgery (V0), week 1 (V1), and 2 (V2) after surgery. VisuEvo® was self-administered three times daily for the whole study duration (group A); the control group (group B) had no tear substitute administration. The primary endpoint was the change in TBUT over time; the secondary endpoints were changes in Ocular Surface Disease Index (OSDI), ocular surface staining, the Schirmer I test, and osmometry. RESULTS:A total of 45 patients were included (group A, 23; group B, 22; age 74?±?8 years). At the screening, TBUT was similar between the groups (group A, 8.5?±?1.8 s; group B, 7.8?±?0.7, p?=?0.11). At the scheduled visits, TBUT increase vs screening visit was significantly higher in group A: +1.2 s at V0, +1.4 s at V1, and +1.9 s at V2 (p?

SUBMITTER: Fogagnolo P 

PROVIDER: S-EPMC7140734 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature