Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC7140797 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Li Jingxuan J Zhao Wenjuan W Li Qianqian Q Huang Ziying Z Shi Gaoli G Li Changchun C
Genes 20200228 3
Long non-coding RNAs (lncRNAs) have been implicated in fundamental and diverse biological processes, including myogenesis. However, the molecular mechanisms involved in this process remain largely unexplored. This study found that H19 affected the differentiation of porcine satellite cells (PSCs) by directly binding to the DNA/RNA-binding protein TDP43. Functional analyses showed that TDP43 knockdown decreased PSC differentiation, whereas TDP43 overexpression exerted opposite effects in vitro. F ...[more]