Ontology highlight
ABSTRACT:
SUBMITTER: Daum R
PROVIDER: S-EPMC7140838 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Daum Ruben R Visser Dmitri D Wild Constanze C Kutuzova Larysa L Schneider Maria M Lorenz Günter G Weiss Martin M Hinderer Svenja S Stock Ulrich A UA Seifert Martina M Schenke-Layland Katja K
Cells 20200323 3
Appropriate mechanical properties and fast endothelialization of synthetic grafts are key to ensure long-term functionality of implants. We used a newly developed biostable polyurethane elastomer (TPCU) to engineer electrospun vascular scaffolds with promising mechanical properties (E-modulus: 4.8 ± 0.6 MPa, burst pressure: 3326 ± 78 mmHg), which were biofunctionalized with fibronectin (FN) and decorin (DCN). Neither uncoated nor biofunctionalized TPCU scaffolds induced major adverse immune resp ...[more]