Ontology highlight
ABSTRACT:
SUBMITTER: Rantapero T
PROVIDER: S-EPMC7140841 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Rantapero Tommi T Wahlfors Tiina T Kähler Anna A Hultman Christina C Lindberg Johan J Tammela Teuvo Lj TL Nykter Matti M Schleutker Johanna J Wiklund Fredrik F
Genes 20200314 3
Germline variants in DNA repair genes are associated with aggressive prostate cancer (PrCa). The aim of this study was to characterize germline variants in DNA repair genes associated with lethal PrCa in Finnish and Swedish populations. Whole-exome sequencing was performed for 122 lethal and 60 unselected PrCa cases. Among the lethal cases, a total of 16 potentially damaging protein-truncating variants in DNA repair genes were identified in 15 men (12.3%). Mutations were found in six genes with ...[more]