Ontology highlight
ABSTRACT:
SUBMITTER: Gallo V
PROVIDER: S-EPMC7141334 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Gallo Vera V Cirillo Emilia E Prencipe Rosaria R Lepore Alessio A Del Vecchio Luigi L Scalia Giulia G Martinelli Vincenzo V Di Matteo Gigliola G Saunders Carol C Durandy Anne A Moschese Viviana V Leonardi Antonio A Giardino Giuliana G Pignata Claudio C
Journal of clinical medicine 20200317 3
Very high IgM levels represent the hallmark of hyper IgM (HIGM) syndromes, a group of primary immunodeficiencies (PIDs) characterized by susceptibility to infections and malignancies. Other PIDs not fulfilling the diagnostic criteria for HIGM syndromes can also be characterized by high IgM levels and susceptibility to malignancies. The aim of this study is to characterize clinical phenotype, immune impairment, and pathogenic mechanism in six patients with very high IgM levels in whom classical H ...[more]