Ontology highlight
ABSTRACT:
SUBMITTER: Ishimaru Y
PROVIDER: S-EPMC7141441 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ishimaru Yuki Y Sumino Akihide A Shibagaki Fumiya F Yamamuro Akiko A Yoshioka Yasuhiro Y Maeda Sadaaki S
Frontiers in aging neuroscience 20200320
Age-associated loss of retinal ganglion cells (RGCs) causes visual deficits, but there is not yet any therapeutic agent to prevent the loss of these cells. Herein, we report that apelin, an endogenous peptide ligand of APJ receptor, is protective against the age-related loss of RGCs in mice. The mRNA expression of apelin was reduced in the retina of old mice compared with that in young mice, whereas retinal APJ expression increased with age. Immunofluorescence staining showed that APJ was presen ...[more]