Unknown

Dataset Information

0

Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals.

ABSTRACT: In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = 0.03). This increase was positively correlated with both the change in the percentage of CD4+ T-cells and with the decrease of CD38+ molecules on Central Memory CD8+ and negatively correlated with the change in the percentage of CD4+ Effector Memory cells. Increase in TL could be an expression of immune reconstitution and the associated decrease in immune activation. We acknowledge for the low statistical power due to the small sample size and the potential for false positive results due to multiple testing. Hence, further studies are needed to confirm these observations.

SUBMITTER: Chalouni M 

PROVIDER: S-EPMC7141657 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals.

Chalouni Mathieu M   Rodriguez-Centeno Javier J   Samri Assia A   Blanco Julian J   Stella-Ascariz Natalia N   Wallet Cedrick C   Knobel Hernando H   Zucman David D   Alejos Ferreras Belen B   Autran Brigitte B   Thiebaut Rodolphe R   Raffi François F   Arribas Jose Ramon JR  

PloS one 20200408 4

In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = 0.03). This increase was positively correlated with both the change in the percentage of CD4+ T-cells and with the decrease of CD38+ molecules on Central Memory CD8+ and negatively correlated with the change in the percentage of CD4+ Effector Memory cells. Increase in TL could  ...[more]

Similar Datasets

Unknown Acute HIV Infection and CD4/CD8 Ratio Normalization After Antiretroviral Therapy Initiation.
| S-EPMC6203616 | biostudies-literature
Unknown Correlation of cord blood telomere length with birth weight.
| S-EPMC5591543 | biostudies-literature
Unknown Impact of Early Antiretroviral Therapy Initiation on HIV-Specific CD4 and CD8 T Cell Function in Perinatally Infected Children.
| S-EPMC6981070 | biostudies-literature
Unknown Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes.
| S-EPMC4764743 | biostudies-literature
Unknown Longitudinal Changes in Cd4+, Cd8+ T Cell Phenotype and Activation Marker Expression Following Antiretroviral Therapy Initiation among Patients with Cryptococcal Meningitis.
| S-EPMC6787641 | biostudies-literature
Unknown Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation.
| S-EPMC4179097 | biostudies-literature
Unknown Effects of 96 Weeks of Rosuvastatin on Bone, Muscle, and Fat in HIV-Infected Adults on Effective Antiretroviral Therapy.
| S-EPMC4817594 | biostudies-literature
Unknown STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets.
| S-EPMC7392054 | biostudies-literature
Unknown Population specific reference ranges of CD3, CD4 and CD8 lymphocyte subsets among healthy Kenyans.
| S-EPMC3827884 | biostudies-other
Unknown HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
| S-EPMC4022662 | biostudies-literature