Deciphering anomalous heterogeneous intracellular transport with neural networks.

ABSTRACT: Intracellular transport is predominantly heterogeneous in both time and space, exhibiting varying non-Brownian behavior. Characterization of this movement through averaging methods over an ensemble of trajectories or over the course of a single trajectory often fails to capture this heterogeneity. Here, we developed a deep learning feedforward neural network trained on fractional Brownian motion, providing a novel, accurate and efficient method for resolving heterogeneous behavior of intracellular transport in space and time. The neural network requires significantly fewer data points compared to established methods. This enables robust estimation of Hurst exponents for very short time series data, making possible direct, dynamic segmentation and analysis of experimental tracks of rapidly

SUBMITTER: Han D 

PROVIDER: S-EPMC7141808 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature