Ontology highlight
ABSTRACT:
SUBMITTER: Klotzl F
PROVIDER: S-EPMC7141870 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Klötzl Fabian F Haubold Bernhard B
Bioinformatics (Oxford, England) 20200401 7
<h4>Motivation</h4>Tracking disease outbreaks by whole-genome sequencing leads to the collection of large samples of closely related sequences. Five years ago, we published a method to accurately compute all pairwise distances for such samples by indexing each sequence. Since indexing is slow, we now ask whether it is possible to achieve similar accuracy when indexing only a single sequence.<h4>Results</h4>We have implemented this idea in the program phylonium and show that it is as accurate as ...[more]