Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC7142014 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Yu Zhibin Z Feng Jianbo J Wang Wei W Deng Zhiyong Z Zhang Yan Y Xiao Lan L Wang Zeyou Z Liu Changhong C Liu Qing Q Chen Shuai S Wu Minghua M
Oncogene 20200213 15
The homeotic protein SIX3 is a transcription factor vital for neurogenesis and has a bivalent promoter. We previously showed that SIX3 can be transcriptionally silenced by DNA hypermethylation, functions as a tumor suppressor gene, and inhibits human glioblastoma transcriptionally. Here, we show that the activation of epidermal growth factor (EGFR) induces DNA methylation of SIX3 promoter through the MAPK pathway. ERK, when activated, binds with ZNF263, consequently abrogating the ubiquitination ...[more]