Ontology highlight
ABSTRACT:
SUBMITTER: Qi SM
PROVIDER: S-EPMC7142254 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Qi Si-Min SM Cheng Gang G Cheng Xiang-Dong XD Xu Zhiyuan Z Xu Beihua B Zhang Wei-Dong WD Qin Jiang-Jiang JJ
Frontiers in cell and developmental biology 20200402
The p53 tumor suppressor protein and its major negative regulators MDM2 and MDMX oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating cancer cell growth, proliferation, cell cycle progression, apoptosis, senescence, angiogenesis, and immune response. Recent studies have shown that the stabilities of p53, MDM2, and MDMX are tightly controlled by the ubiquitin-proteasome system. Ubiquitin specific protease 7 (USP7), one of the most studied deubiquitinating enzyme ...[more]