Ontology highlight
ABSTRACT:
SUBMITTER: Souto EB
PROVIDER: S-EPMC7142522 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Souto Eliana B EB Campos Joana R JR Da Ana Raquel R Martins-Gomes Carlos C Silva Amélia M AM Souto Selma B SB Lucarini Massimo M Durazzo Alessandra A Santini Antonello A
International journal of environmental research and public health 20200319 6
Genotoxicity screening tests aim to evaluate if and to what extent a compound in contact with the human body (e.g., a drug molecule, a compound from the environment) interacts with DNA. The comet assay is a sensitive method used to predict the risk of DNA damage in individual cells, as it quantifies the tape breaks, being the alkaline version (pH > 13) the most commonly used in the laboratory. Epithelial cells serve as biomatrices in genotoxicity assessments. As ca. 80% of solid cancers are of e ...[more]