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Sesquiterpenes and Cyclodepsipeptides from Marine-Derived Fungus Trichoderma longibrachiatum and Their Antagonistic Activities against Soil-borne Pathogens.


ABSTRACT: Soil-borne pathogens, including phytopathogenic fungi and root-knot nematodes, could synergistically invade vegetable roots and result in serious economic losses. The genus of Trichoderma has been proven to be a promising reservoir of biocontrol agents in agriculture. In this study, the search for antagonistic metabolites from a marine-derived fungus, Trichoderma longibrachiatum, obtained two structural series of sesquiterpenes 1-6 and cyclodepsipeptides 7-9. Notably, the novel 1 was a rare norsesquiterpene characterized by an unprecedented tricyclic-6/5/5-[4.3.1.01,6]-decane skeleton. Their structures were elucidated by extensive spectroscopic analyses, while the absolute configuration of novel 1 was determined by the comparison of experimental and calculated ECD spectra. The novel 1 and known 2 and 3 showed significant antifungal activities against Colletotrichum lagrnarium with MIC values of 8, 16, and 16 ?g/mL respectively, even better than those of the commonly used synthetic fungicide carbendazim with 32 ?g/mL. They also exhibited antifungal potential against carbendazim-resistant Botrytis cinerea. Cyclodepsipeptides 7-9 showed moderate nematicidal activities against the southern root-knot nematode (Meloidogyne incognita). This study constitutes the first report on the antagonistic effects of metabolites from T. Longibrachiatum against soil-borne pathogens, also highlighting the integrated antagonistic potential of marine-derived T. Longibrachiatum as a biocontrol agent.

SUBMITTER: Du FY 

PROVIDER: S-EPMC7142749 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Sesquiterpenes and Cyclodepsipeptides from Marine-Derived Fungus <i>Trichoderma longibrachiatum</i> and Their Antagonistic Activities against Soil-borne Pathogens.

Du Feng-Yu FY   Ju Guang-Lin GL   Xiao Lin L   Zhou Yuan-Ming YM   Wu Xia X  

Marine drugs 20200316 3


Soil-borne pathogens, including phytopathogenic fungi and root-knot nematodes, could synergistically invade vegetable roots and result in serious economic losses. The genus of <i>Trichoderma</i> has been proven to be a promising reservoir of biocontrol agents in agriculture. In this study, the search for antagonistic metabolites from a marine-derived fungus, <i>Trichoderma longibrachiatum,</i> obtained two structural series of sesquiterpenes <b>1</b>-<b>6</b> and cyclodepsipeptides <b>7</b>-<b>9  ...[more]

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