Ontology highlight
ABSTRACT:
SUBMITTER: Vakal S
PROVIDER: S-EPMC7144023 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Vakal Serhii S Jalkanen Sirpa S Dahlström Käthe M KM Salminen Tiina A TA
Molecules (Basel, Switzerland) 20200312 6
Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme. hVAP-1-targeted inhibitors are designed to treat inflammatory diseases and cancer, whereas the off-target binding of the designed inhibitors to hDAO might r ...[more]