Ontology highlight
ABSTRACT:
SUBMITTER: Rozman K
PROVIDER: S-EPMC7144120 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Rožman Kaja K Alexander Evan M EM Ogorevc Eva E Bozovičar Krištof K Sosič Izidor I Aldrich Courtney C CC Gobec Stanislav S
Molecules (Basel, Switzerland) 20200312 6
Protein degradation is a fundamental process in all living organisms. An important part of this system is a multisubunit, barrel-shaped protease complex called the proteasome. This enzyme is directly responsible for the proteolysis of ubiquitin- or pup-tagged proteins to smaller peptides. In this study, we present a series of 92 psoralen derivatives, of which 15 displayed inhibitory potency against the <i>Mycobacterium tuberculosis</i> proteasome in low micromolar concentrations. The best inhibi ...[more]