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Effect of Terpenoids and Flavonoids Isolated from Baccharis conferta Kunth on TPA-Induced Ear Edema in Mice.


ABSTRACT: In this study, we isolated from the aerial parts of Baccharis conferta Kunth (i) a new neoclerodane, denominated "bacchofertone"; (ii) four known terpenes: schensianol A, bacchofertin, kingidiol and oleanolic acid; and (iii) two flavonoids: cirsimaritin and hispidulin. All structures were identified by an exhaustive analysis of nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Extracts from aerial parts were screened for anti-inflammatory activity in the mice ear edema model of 12-O-tetradecanoylforbol-13-acetate mice. Dichloromethane extract (BcD) exhibited 78.5 ± 0.72% inhibition of edema, followed by the BcD2 and BcD3 fractions of 71.4% and 82.9% respectively, at a dose of 1 mg/ear. Kingidiol and cirsimaritin were the most potent compounds identified, with a median effective dose of 0.12 and 0.16 mg/ear, respectively. A histological analysis showed that the topical application of TPA promoted intense cell infiltration, and this inflammatory parameter was reduced with the topical application of isolated compounds.

SUBMITTER: Ana Silvia GR 

PROVIDER: S-EPMC7144369 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Effect of Terpenoids and Flavonoids Isolated from <i>Baccharis conferta</i> Kunth on TPA-Induced Ear Edema in Mice.

Ana Silvia Gutiérrez-Román GR   Gabriela Trejo-Tapia TT   Maribel Herrera-Ruiz HR   Nayeli Monterrosas-Brisson MB   José Luis Trejo-Espino TE   Alejandro Zamilpa Z   Manasés González-Cortazar GC  

Molecules (Basel, Switzerland) 20200318 6


In this study, we isolated from the aerial parts of <i>Baccharis conferta</i> Kunth (i) a new neoclerodane, denominated "bacchofertone"; (ii) four known terpenes: schensianol A, bacchofertin, kingidiol and oleanolic acid; and (iii) two flavonoids: cirsimaritin and hispidulin. All structures were identified by an exhaustive analysis of nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Extracts from aerial parts were screened for anti-inflammatory activity in the mice ear edema model of  ...[more]

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