Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Salazar C
PROVIDER: S-EPMC7144534 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Diaz-Salazar Carlos C Bou-Puerto Regina R Mujal Adriana M AM Lau Colleen M CM von Hoesslin Madlaina M Zehn Dietmar D Sun Joseph C JC
The Journal of experimental medicine 20200401 4
Natural killer (NK) cells are innate lymphocytes that exhibit adaptive features, such as clonal expansion and memory, during viral infection. Although activating receptor engagement and proinflammatory cytokines are required to drive NK cell clonal expansion, additional stimulatory signals controlling their proliferation remain to be discovered. Here, we describe one such signal that is provided by the adrenergic nervous system, and demonstrate that cell-intrinsic adrenergic signaling is require ...[more]