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Cerebrosides and Steroids from the Edible Mushroom Meripilus giganteus with Antioxidant Potential.

ABSTRACT: The detailed chemical analysis of the methanol extract of Meripilus giganteus (Pers.) P. Karst. led to the isolation of two new cerebrosides, mericeramides A (1) and B (2) together with cerebroside B (3), ergosterol (4), 3?-hydroxyergosta-7,22-diene (5), cerevisterol (6), 3?-hydroxyergosta-6,8(14),22-triene (7), 3?-O-glucopyranosyl-5,8-epidioxyergosta-6,22-diene (8) and (11E,13E)-9,10-dihydroxy-11,13-octadecadienoic acid (9). The structures of the compounds were determined on the basis of NMR and MS spectroscopic analysis. Mericeramide A (1) is the first representative of halogenated natural cerebrosides. The isolated fungal metabolites 1-9 were evaluated for their antioxidant activity using the oxygen radical absorbance capacity (ORAC) assay. Compounds 2, 5 and 9 proved to possess considerable antioxidant effects, with 2.50 ± 0.29, 4.94 ± 0.37 and 4.27 ± 0.05 mmol TE/g values, respectively. The result obtained gives a notable addition to the chemical and bioactivity profile of M. giganteus, highlighting the possible contribution of this species to a versatile and balanced diet.

SUBMITTER: Sarkozy A

PROVIDER: S-EPMC7144561 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Cerebrosides and Steroids from the Edible Mushroom Meripilus giganteus with Antioxidant Potential.

Sárközy András A Béni Zoltán Z Dékány Miklós M Zomborszki Zoltán Péter ZP Rudolf Kinga K Papp Viktor V Hohmann Judit J Ványolós Attila A

Molecules (Basel, Switzerland) 20200319 6

The detailed chemical analysis of the methanol extract of Meripilus giganteus (Pers.) P. Karst. led to the isolation of two new cerebrosides, mericeramides A (1) and B (2) together with cerebroside B (3), ergosterol (4), 3β-hydroxyergosta-7,22-diene (5), cerevisterol (6), 3β-hydroxyergosta-6,8(14),22-triene (7), 3β-O-glucopyranosyl-5,8-epidioxyergosta-6,22-diene (8) and (11E,13E)-9,10-dihydroxy-11,13-octadecadien ...[more]

PMID: 32204362

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Dataset Information

Cerebrosides and Steroids from the Edible Mushroom Meripilus giganteus with Antioxidant Potential.

Publications

Cerebrosides and Steroids from the Edible Mushroom <i>Meripilus giganteus</i> with Antioxidant Potential.

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