Ontology highlight
ABSTRACT:
SUBMITTER: Caldwell MA
PROVIDER: S-EPMC7144623 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Caldwell Michael A MA Brue Christopher R CR Whittemore Tyler J TJ Meade Thomas J TJ
RSC advances 20200303 15
Differences in tissue pH can be diagnostic of cancer and other conditions that shift cell metabolism. Paramagnetic probes are promising tools for pH mapping in vivo using magnetic resonance spectroscopy (MRS) as they provide uniquely shifted MR signals that change with pH. Here, we demonstrate a 3-hydroxy-6-methylpyridyl coordinating group as a new pH-responsive reporter group for Ln(III) MRS probes. The pH response of the complex was observed by UV-Vis, fluorescence, and NMR spectroscopies, and ...[more]